A rare γ-pyranopyrazole skeleton: design, one-pot synthesis and computational study. Issue 31 (13th July 2016)

• Record Type: Journal Article
• Authors: Üçüncü, Muhammed; Cantürk, Ceren; Karakuş, Erman; Zeybek, Hüseyin; Bozkaya, Uğur; Soydaş, Emine; Şahin, Ertan; Emrullahoğlu, Mustafa
• Is Part Of: Organic & biomolecular chemistry. Volume 14:Issue 31(2016)
• Page Start: 7490
• Page End: 7494
• Publication Date: 2016-07-13
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob01099g
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A base mediated one-pot, two-step synthetic method for constructing γ-pyranopyrazoles. Abstract : Drawing upon a consecutive amide coupling and intramolecular cyclisation pathway, a one-pot, straightforward synthetic route has been developed for a range of pyrazole fused γ-pyrone derivatives. The reaction mechanism proposed for the chemoselective formation of γ-pyranopyrazole is furthermore fully supported by experimental and computational studies.