Fluorescent vinblastine probes for live cell imaging. Issue 64 (21st July 2016)

• Record Type: Journal Article
• Authors: Meimetis, Labros G.; Giedt, Randy J.; Mikula, Hannes; Carlson, Jonathan C.; Kohler, Rainer H.; Pirovich, David B.; Weissleder, Ralph
• Is Part Of: Chemical communications. Volume 52:Issue 64(2016)
• Page Start: 9953
• Page End: 9956
• Publication Date: 2016-07-21
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c6cc04129a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : We describe the synthesis of several fluorescent analogues of the clinically approved microtubule destabilizing agent vinblastine. The evaluated probes are the most potent described and provides the first example of uptake, distribution and live cell imaging of this well known antimitotic agent. Abstract : Herein we describe the synthesis of several fluorescent analogues of the clinically approved microtubule destabilizing agent vinblastine. The evaluated probes are the most potent described and provides the first example of uptake, distribution and live cell imaging using this well known antimitotic agent.