Alterations of calcium homeostasis in cancer cells. (August 2016)

• Record Type: Journal Article
• Authors: Marchi, Saverio; Pinton, Paolo
• Is Part Of: Current opinion in pharmacology. Volume 29(2016)
• Page Start: 1
• Page End: 6
• Publication Date: 2016-08
• Subjects: Pharmacology -- Periodicals; Pharmaceutical Preparations -- Periodicals; Drug Therapy -- Periodicals; Biopharmaceutics -- Periodicals; Pharmacologie -- Périodiques; Pharmacology; Periodicals; 615.105
• DOI: 10.1016/j.coph.2016.03.002
• Languages: English
• ISSNs: 1471-4892

Abstract

Highlights: Altered Ca 2+ homeostasis is a hallmark of cancer cells. Deregulation of cytosolic [Ca 2+ ] is implicated in metastasis and apoptosis-resistance. Genes involved in cancer influence [Ca 2+ ] to exert their tumor-related functions. Abstract : Typical hallmarks of cancer include programmed cell death evasion, uncontrolled cell growth, invasion, and metastasis. Changes in intracellular Ca 2+ levels can modulate signaling pathways that control a broad range of cellular events, including those important to tumorigenesis and cancer progression. Here we discuss how known molecular mediators of cellular Ca 2+ homeostasis impact tumor dynamics and how deregulation of major oncogenes and tumor suppressors is tightly associated with Ca 2+ signaling.