A SNARE and specific COPII requirements define ER-derived vesicles for the biogenesis of autophagosomes. Issue 6 (2nd June 2016)

• Record Type: Journal Article
• Authors: Lemus, Leticia; Goder, Veit
• Is Part Of: Autophagy. Volume 12:Issue 6(2016)
• Page Start: 1049
• Page End: 1050
• Publication Date: 2016-06-02
• Subjects: autophagy -- COPII -- membrane fusion -- membrane traffic -- SNARE proteins; Autophagic vacuoles -- Periodicals; Apoptosis -- Periodicals; Cell death -- Periodicals; Lysosomes -- Periodicals; Degeneration (Pathology) -- Periodicals; Autophagy -- Periodicals; Cell Death -- Periodicals; Lysosomes -- Periodicals; Periodicals; 571.936
• DOI: 10.1080/15548627.2016.1164368
• Languages: English
• ISSNs: 1554-8627

Abstract

ABSTRACT: The endoplasmic reticulum (ER) is a major source for the generation of autophagosomes during macroautophagy. Our recent work in yeast shows that particular ER-derived vesicles are generated for the biogenesis of autophagosomes. These vesicles not only incorporate a SNARE protein that is largely ER-resident under nonstarving conditions, but also display COPII requirements for ER-exit that differ from conventional cargo-transporting vesicles. Our results suggest that specific intracellular traffic is launched at the ER for the transport of membranes to sites of autophagosome formation.