Frameshift mutations, neoantigens and tumor-specific CD8+ T cells in microsatellite unstable colorectal cancers. (3rd May 2016)

• Record Type: Journal Article
• Authors: Maby, Pauline; Galon, Jérôme; Latouche, Jean-Baptiste
• Is Part Of: Oncoimmunology. Volume 5:Number 5(2016)
• Publication Date: 2016-05-03
• Subjects: Adoptive cell transfer -- colorectal cancer -- frameshift mutation -- immunotherapy -- microsatellite instablility -- neoantigen -- neopeptide -- tumor-specific CD8+ T cell; Tumors -- Immunological aspects -- Periodicals; Neoplasms -- therapy -- Periodicals; Immunotherapy -- Periodicals; 616.994
• DOI: 10.1080/2162402X.2015.1115943
• Languages: English
• ISSNs: 2162-402X

Abstract

ABSTRACT: Microsatellite unstable colorectal cancers (CRC) express frameshift mutation-derived tumor-specific neoantigens. We recently showed that: (i) frameshift mutations were correlated with tumor-infiltrating CD8 + T cell density, (ii) neoantigen-specific cytotoxic T cells could be obtained in patients whose tumors harbored these mutations, underlining the interest of developing personalized immunotherapy strategies in these cancers.