Unlocking tumor vascular barriers with CXCR3: Implications for cancer immunotherapy. (3rd May 2016)

• Record Type: Journal Article
• Authors: Mikucki, Maryann E.; Skitzki, Joseph J.; Frelinger, John G.; Odunsi, Kunle; Gajewski, Thomas F.; Luster, Andrew D.; Evans, Sharon S.
• Is Part Of: Oncoimmunology. Volume 5:Number 5(2016)
• Publication Date: 2016-05-03
• Subjects: Adoptive T cell transfer -- cancer immunotherapy -- chemokine receptor -- CXCR3 -- T cell trafficking -- tumor vessels; Tumors -- Immunological aspects -- Periodicals; Neoplasms -- therapy -- Periodicals; Immunotherapy -- Periodicals; 616.994
• DOI: 10.1080/2162402X.2015.1116675
• Languages: English
• ISSNs: 2162-402X

Abstract

ABSTRACT: Promising cancer immunotherapeutics depend on mobilization of cytotoxic T cells across tumor vascular barriers through mechanisms that are poorly understood. Recently, we discovered that the CXCR3 chemokine receptor uniquely functions as the master-regulator of cytotoxic CD8 + T cell extravasation and tumor control despite the multiplicity of chemokines available in the tumor landscape.