Positive impact of autophagy in human breast cancer cells on local immunosurveillance. (2nd June 2016)

• Record Type: Journal Article
• Authors: Ladoire, Sylvain; Enot, David; Senovilla, Laura; Chaix, Marie; Zitvogel, Laurence; Kroemer, Guido
• Is Part Of: Oncoimmunology. Volume 5:Number 6(2016)
• Publication Date: 2016-06-02
• Subjects: Autophagy -- breast cancer -- LC3 -- lymphocytes -- macrophages -- Treg cells.; Tumors -- Immunological aspects -- Periodicals; Neoplasms -- therapy -- Periodicals; Immunotherapy -- Periodicals; 616.994
• DOI: 10.1080/2162402X.2016.1174801
• Languages: English
• ISSNs: 2162-402X

Abstract

ABSTRACT: In human breast cancer cells, the presence of cytoplasmic dots positive for microtubule-associated proteins 1A/1B light chain 3B (LC3B) indicates enhanced autophagic flux and favorable prognosis. LC3B + puncta within malignant cells positively correlate with the intratumoral abundance of CD8 + cytotoxic T lymphocytes, yet negatively correlate with the frequency of local FOXP3 + regulatory T cells and CD68 + tumor-associated macrophages, resulting in an improvement of CD8 + /FOXP + or CD8 + /CD68 + ratios.