Prostate cancer: from Gleason scoring to prognostic grade grouping. Issue 4 (2nd April 2016)

• Record Type: Journal Article
• Authors: Montironi, Rodolfo; Santoni, Matteo; Mazzucchelli, Roberta; Burattini, Luciano; Berardi, Rossana; Galosi, Andrea B.; Cheng, Liang; Lopez-Beltran, Antonio; Briganti, Alberto; Montorsi, Francesco; Scarpelli, Marina
• Is Part Of: Expert review of anticancer therapy. Volume 16:Issue 4(2016)
• Page Start: 433
• Page End: 440
• Publication Date: 2016-04-02
• Subjects: Prostate cancer -- Gleason grading -- International society of urological pathology -- 2005 ISUP Gleason modified system -- 2014 ISUP Gleason modified system -- prognostic grade grouping; Cancer -- Treatment -- Periodicals; 616.99406
• DOI: 10.1586/14737140.2016.1160780
• Languages: English
• ISSNs: 1473-7140

Abstract

ABSTRACT: The Gleason grading system was developed in the late 1960s by Dr. Donald F. Gleason. Due to changes in prostatic adenocarcinoma (PAC) detection and treatment, newer technologies to better characterize prostatic pathology, subsequently described variants of PAC and further data relating various morphologic patterns to prognosis, the application of the Gleason grading system changed substantially in surgical pathology. First in 2005 and more recently in 2014, consensus conferences were held to update PAC grading. Here, we review of the successive changes in the grading of PAC from the original system, with emphasis on the newest prognostic grade grouping.