Interpreting IgE sensitization tests in food allergy. (2nd April 2016)

• Record Type: Journal Article
• Authors: Chokshi, Niti Y.; Sicherer, Scott H.
• Is Part Of: Expert review of clinical immunology. Volume 12:Number 4(2016)
• Page Start: 389
• Page End: 403
• Publication Date: 2016-04-02
• Subjects: Food allergy -- diagnosis -- food-specific IgE -- component-resolved diagnostics -- milk allergy -- peanut allergy -- egg allergy -- soy allergy -- wheat allergy -- seafood allergy; Clinical immunology -- Periodicals; 616.079
• DOI: 10.1586/1744666X.2016.1124761
• Languages: English
• ISSNs: 1744-666X

Abstract

ABSTRACT: Food allergies are increasing in prevalence, and with it, IgE testing to foods is becoming more commonplace. Food-specific IgE tests, including serum assays and prick skin tests, are sensitive for detecting the presence of food-specific IgE (sensitization), but specificity for predicting clinical allergy is limited. Therefore, positive tests are generally not, in isolation, diagnostic of clinical disease. However, rationale test selection and interpretation, based on clinical history and understanding of food allergy epidemiology and pathophysiology, makes these tests invaluable. Additionally, there exist highly predictive test cutoff values for common allergens in atopic children. Newer testing methodologies, such as component resolved diagnostics, are promising for increasing the utility of testing. This review highlights the use of IgE serum tests in the diagnosis of food allergy.