Long-term local control and survival after preoperative radiochemotherapy in combination with deep regional hyperthermia in locally advanced rectal cancer. (17th February 2016)

• Record Type: Journal Article
• Authors: Gani, Cihan; Schroeder, Christopher; Heinrich, Vanessa; Spillner, Patrick; Lamprecht, Ulf; Berger, Bernhard; Zips, Daniel
• Is Part Of: International journal of hyperthermia. Volume 32:Number 2(2016)
• Page Start: 187
• Page End: 192
• Publication Date: 2016-02-17
• Subjects: Chemoradiotherapy -- disease-free survival -- hyperthermia -- local control -- overall survival -- radiochemotherapy -- rectal cancer; Thermotherapy -- Periodicals; 615.832
• DOI: 10.3109/02656736.2015.1117661
• Languages: English
• ISSNs: 0265-6736

Abstract

Abstract: Purpose : The aim of this study was to evaluate the impact of deep regional hyperthermia on long-term local control and survival in locally advanced non-metastatic rectal cancer. Methods : In total 103 patients with locally advanced non-metastatic rectal cancer were treated preoperatively with either neoadjuvant radiochemotherapy alone ( n = 43) or the same treatment with additional deep regional hyperthermia ( n = 60). The two groups were compared with respect to local control, overall survival (OS), disease-free survival (DFS), and distant metastases-free survival (DMFS). Results : Patients receiving additional hyperthermia had excellent long-term local control with a 5-year Kaplan-Meier estimate of 98% compared with 87% in the radiochemotherapy only group ( p = 0.09). Five-year rates for OS (88% versus 76%, p = 0.08), DFS (77% versus 73%, p = n.s.) and DMFS (75% versus 77%, p = n.s.) were not statistically different between the two groups. Conclusion : Radiochemotherapy combined with hyperthermia results in excellent long-term local control.