The association of the Klotho polymorphism rs9536314 with parameters of calcium-phosphate metabolism in patients on long-term hemodialysis. (27th May 2016)

• Record Type: Journal Article
• Authors: Marchelek-Myśliwiec, Małgorzata; Różański, Jacek; Ogrodowczyk, Aldona; Dutkiewicz, Grażyna; Dołęgowska, Barbara; Sałata, Daria; Budkowska, Marta; Safranow, Krzysztof; Stępniewska, Joanna; Wiśniewska, Magda; Ciechanowski, Kazimierz
• Is Part Of: Renal failure. Volume 38:Number 5(2016)
• Page Start: 776
• Page End: 780
• Publication Date: 2016-05-27
• Subjects: FGF23 -- hemodialysis -- Klotho polymorphism; Chronic renal failure -- Periodicals; Acute renal failure -- Periodicals; Uremia -- Periodicals; 616.614005
• DOI: 10.3109/0886022X.2016.1162062
• Languages: English
• ISSNs: 0886-022X

Abstract

Abstract: Background : Patients on long-term hemodialysis frequently suffer from complications, such as secondary hyperparathyroidism, bone fractures, and arteriosclerosis. The process of regulating Ca/P metabolism depends on factors, such as FGF23 and Klotho. This study aimed to answer the question of whether the Klotho polymorphism rs9536314 is associated with FGF23 plasma concentration.Methods : In 118 patients undergoing hemodialysis, blood was collected before and after hemodialysis. The following parameters were measured in plasma: FGF23, serum: Ca, P, PTH, HGB, and iron concentrations. The KL gene polymorphism rs9536314 was identified by PCR-RFLP.Results : The KL polymorphism rs9536314 was not associated with Ca, P, PTH, or FGF23. There was a negative correlation between FGF23 and blood HGB levels and positive correlation between FGF23 and ESA dose.Conclusions : The results obtained may indicate that there is no association between the KL polymorphism and FGF23 concentration in patients undergoing long-term.