Second trimester amniotic fluid myo-inositol concentrations in women later developing gestational diabetes mellitus or pregnancy-induced hypertension. (17th July 2016)

• Record Type: Journal Article
• Authors: Santamaria, Angelo; Corrado, Francesco; Baviera, Giovanni; Carlomagno, Gianfranco; Unfer, Vittorio; D'anna, Rosario
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 29:Number 14(2016)
• Page Start: 2245
• Page End: 2247
• Publication Date: 2016-07-17
• Subjects: Amniotic fluid -- fetal metabolism -- gestational diabetes -- gestational hypertension -- myo-inositol; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.3109/14767058.2015.1081886
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Objective : To evaluate myo-inositol concentrations in amniotic fluid in women later developing gestational diabetes and hypertension. Methods : A retrospective study was carried out with three groups of amniotic fluid samples (15–18 gestational weeks): 30 gestational hypertension pregnancies, 30 gestational diabetes pregnancies, and 30 normal pregnancy. Results : A significant difference was observed in myo-inositol concentrations between the median gestational diabetes values (124.0 µmol/L, IQR 90.0–162.5) and the control group values (79.0 µmol/L, IQR 62.0–107.5), but also with gestational hypertension median values (79.0 µmol/L, IQR 67.75–92.0) ( p < 0.001). Conclusions : This study has shown that myo-inositol concentrations in amniotic fluid increased significantly in women later developing gestational diabetes compared to the control group.