Dynamic collagen changes in cervix during the first trimester and decreased collagen content in cervical insufficiency. (16th September 2016)

• Record Type: Journal Article
• Authors: Gedikbasi, Asuman; Yücel, Burak; Arslan, Oguz; Giris, Murat; Gedikbasi, Ali; Abbasoglu, Semra Dogru
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 29:Number 18(2016)
• Page Start: 2968
• Page End: 2972
• Publication Date: 2016-09-16
• Subjects: Cervical insufficiency -- collagen -- hydroxyproline -- uterine cervical incompetence; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.3109/14767058.2015.1109623
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Objective : To determine the changes in cervical collagen during the first trimester of pregnancy and to evaluate the collagen deficit in cases with a previous diagnosis of cervical insufficiency (CI). Materials and methods : Cervical punch biopsies were obtained from 66 patients divided into three groups: patients with recurrent abortions due to CI (CI group; n = 8); first-trimester abortion group (study group; n = 37), subdivided into three groups according their gestational week (<7, 7–9 and 9–12 weeks), and patients with cervical biopsy due to gynecologic reasons (control group; n = 12). Collagen quantity was determined by a biochemical method that measured the levels of hydroxyproline (HOP) in dry cervix tissue. Results : The HOP concentrations were significantly higher at lower gestational ages ( p = 0.001). Collagen quantity was lowest in the CI group compared with other groups ( p < 0.001). Conclusion : This study shows collagen component of cervix decreases as pregnancy advances through the first trimester. Cervical collagen concentration is lower in women with a history of CI compared to controls who has not a history of CI.