In vivo evaluation of novel ketal-based oligosaccharides of hyaluronan micelles as multifunctional CD44 receptor-targeting and tumor pH-responsive carriers. (2nd April 2016)

• Record Type: Journal Article
• Authors: Chen, Daquan; Sun, Jingfang; Sun, Kaoxiang; Liu, Wanhui; Wu, Zimei
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 44:Number 3(2016)
• Page Start: 898
• Page End: 902
• Publication Date: 2016-04-02
• Subjects: cellular uptake -- CD44 receptor-targeting -- oligosaccharides of hyaluronan -- oHA-histidine-menthone 1, 2-glycerol ketal; Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.3109/21691401.2014.998828
• Languages: English
• ISSNs: 2169-1401

Abstract

Abstract : In this report, the oligosaccharides of hyaluronan (oHA)-histidine-menthone 1, 2-glycerol ketal (MGK) (oHM) carried pH-sensitive MGK as hydrophobic moieties and oHA as the target of the CD44 receptor. The oHM could self-assemble, with a diameter of 65 nm. The cellular uptake, indicated by the fluorescent signals, was higher at 4 h. The ex vivo imaging indicated that micelles have a longer blood circulation, beyond 5 h. The fluorescence intensity of the micelles in the liver and spleen was much higher from 5 to 24 h. The CD44 receptor-targeting, indicated by the fluorescence signals of A549 and MDA-MB-231 group, were higher than those of the HepG2 and the control.