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ChemInform Abstract: Synthesis of Chiral 4, 5‐Dihydrothiazol‐2‐amines and 4, 5‐Dihydrooxazol‐2‐amines Through an Unexpected Ring Opening Reaction of Azetidines. Issue 28 (June 2016)
Record Type:
Journal Article
Title:
ChemInform Abstract: Synthesis of Chiral 4, 5‐Dihydrothiazol‐2‐amines and 4, 5‐Dihydrooxazol‐2‐amines Through an Unexpected Ring Opening Reaction of Azetidines. Issue 28 (June 2016)
Main Title:
ChemInform Abstract: Synthesis of Chiral 4, 5‐Dihydrothiazol‐2‐amines and 4, 5‐Dihydrooxazol‐2‐amines Through an Unexpected Ring Opening Reaction of Azetidines.
Abstract: Chiral azetidines (I) react with isocyanates or isothiocyanates to form the corresponding urea intermediates, which undergo a completely regio‐ and stereoselective ring opening reaction to furnish oxazoles (IV) or thiazoles (VI).