Characterization, expression analysis and localization pattern of toll‐like receptor 1 (tlr1) and toll‐like receptor 2 (tlr2) genes in grass carp Ctenopharyngodon idella. Issue 2 (25th May 2016)

• Record Type: Journal Article
• Authors: He, L. B.; Wang, H.; Luo, L. F.; Jiang, S. H.; Liu, L. Y.; Li, Y. M.; Huang, R.; Liao, L. J.; Zhu, Z. Y.; Wang, Y. P.
• Is Part Of: Journal of fish biology. Volume 89:Issue 2(2016)
• Page Start: 1434
• Page End: 1440
• Publication Date: 2016-05-25
• Subjects: grass carp Ctenopharyngodon idellus -- grass carp reovirus -- immune response -- toll‐like receptor 1 -- toll‐like receptor 2; Fishes -- Periodicals; Fishes -- Great Britain -- Periodicals; 597
• DOI: 10.1111/jfb.12997
• Languages: English
• ISSNs: 0022-1112

Abstract

Abstract : In this study, the toll‐like receptor 1 ( tlr1 ) and toll‐like receptor 2 ( tlr2 ) genes of grass carp Ctenopharyngodon idella were cloned and characterized. tlr1 and tlr2 were found to be highly expressed in immune system organs such as spleen, middle kidney and heart kidney. The expression level of tlr1 and tlr2 was found to be up‐regulated at the later stage of viral challenge process. Moreover, subcellular localization indicated that Tlr1 and Tlr2 shared similar localization pattern and both of them may locate in the plasma membrane of transfected cells.