60 YEARS OF POMC: POMC: an evolutionary perspective. (May 2016)

• Record Type: Journal Article
• Authors: Navarro, Sandra; Soletto, Lucia; Puchol, Sara; Rotllant, Josep; Soengas, Jose Luis; Cerdá-Reverter, Jose Miguel
• Is Part Of: Journal of molecular endocrinology. Volume 56:Number 4(2016)
• Page Start: T113
• Page End: T118
• Publication Date: 2016-05
• Subjects: proopiomelanocortin -- MSH -- ACTH -- β-endorphin -- opioid -- evolution; Molecular endocrinology -- Periodicals; Endocrinology -- Periodicals; 616.407
• DOI: 10.1530/JME-15-0288
• Languages: English
• ISSNs: 0952-5041

Abstract

Abstract : Proopiomelanocortin (POMC) is a complex precursor that comprises several peptidic hormones, including melanocyte-stimulating hormones (MSHs), adrenocorticotropic hormone (ACTH), and β-endorphin. POMC belongs to the opioid/orphanin gene family, whose precursors include either opioid (YGGF) or the orphanin/nociceptin core sequences (FGGF). This gene family diversified during early tetraploidizations of the vertebrate genome to generate four different precursors: proenkephalin (PENK), prodynorphin (PDYN), and nociceptin/proorphanin (PNOC) as well as POMC, although both PNOC and POMC seem to have arisen due to a local duplication event. POMC underwent complex evolutionary processes, including internal tandem duplications and putative coevolutionary events. Controversial and conflicting hypotheses have emerged concerning the sequenced genomes. In this article, we summarize the different evolutionary hypotheses proposed for POMC evolution.