Synthesis and quality control of [18F]T807 for tau PET imaging. (17th July 2016)

• Record Type: Journal Article
• Authors: Holt, Daniel P.; Ravert, Hayden T.; Dannals, Robert F.
• Is Part Of: Journal of labelled compounds & radiopharmaceuticals. Volume 59:Number 10(2016)
• Page Start: 411
• Page End: 415
• Publication Date: 2016-07-17
• Subjects: fluorine‐18 -- microwave -- tau -- PET -- quality control; Tracers (Chemistry) -- Periodicals; Radiopharmaceuticals -- Periodicals; 615.8424
• DOI: 10.1002/jlcr.3425
• Languages: English
• ISSNs: 0362-4803

Abstract

Abstract : The detailed synthesis and quality control of [ 18 F]T807, radiotracer for tau protein aggregate imaging, are described. The radiotracer synthesis was accomplished in an average of 48 min with an average specific activity at end‐of‐synthesis of over 4.4 TBq/µmole (120 Ci/µmole) and an average radiochemical yield of 32%. Compliance with all standard US Pharmacopeia Chapter <823> acceptance tests was observed. Abstract : The detailed synthesis and quality control of [ 18 F]T807, radiotracer for tau protein aggregate imaging, are described. The radiotracer synthesis was accomplished in an average of 48 min with an average specific activity at end‐of‐synthesis of over 4.4 TBq/μmole (120 Ci/μmole) and an average radiochemical yield of 32%. Compliance with all standard USP Chapter <823> acceptance tests was observed.