RhIII‐Catalyzed Hydroarylation of Internal Alkynes through C−H Bond Activation. Issue 8 (3rd June 2016)

• Record Type: Journal Article
• Authors: Wang, Cheng‐Qiang; Feng, Chao; Loh, Teck‐Peng
• Is Part Of: Asian journal of organic chemistry. Volume 5:Issue 8(2016)
• Page Start: 1002
• Page End: 1007
• Publication Date: 2016-06-03
• Subjects: alkynes -- C−H activation -- cross-coupling -- hydroarylation -- rhodium; Chemistry, Organic -- Periodicals; Organic compounds -- Synthesis -- Periodicals; 547.005
• DOI: 10.1002/ajoc.201600144
• Languages: English
• ISSNs: 2193-5807

Abstract

Abstract: Rh III ‐catalyzed hydroarylation of internal alkynes through C−H bond activation is described herein by using N, N ‐dimethylaminocarbonyl as a directing group without the need of an external oxidant. This protocol exhibits exceptional functionality compatibility owing to its extremely mild reaction conditions, which provides a facile and highly efficient synthetic method for olefin moiety introduction. Abstract : Directing hydroarylation : Rh III ‐catalyzed hydroarylation of internal alkynes through C−H bond activation is described by using N, N ‐dimethylaminocarbonyl as a directing group. This protocol enables exceptional functionality compatibility because of the mild reaction conditions employed and provides a highly efficient route for the introduction of olefins. By taking advantage of the difference of innate binding abilities of the assisting group, consecutive introduction of two different types of alkene moiety was readily realized.