Cobalt‐Catalyzed C−H Functionalizations by Imidate Assistance with Aryl and Alkyl Chlorides. Issue 15 (8th July 2016)

• Record Type: Journal Article
• Authors: Mei, Ruhuai; Ackermann, Lutz
• Is Part Of: Advanced synthesis & catalysis. Volume 358:Issue 15(2016)
• Page Start: 2443
• Page End: 2448
• Publication Date: 2016-07-08
• Subjects: alkylation -- arylation -- C−H activation -- chlorides -- cobalt -- imidates -- N-heterocyclic carbene ligands; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201600384
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: A catalytic system comprising the inexpensive cobalt(II) acetylacetonate [Co(acac)2 ] and an N‐heterocyclic carbene (NHC) ligand enabled versatile C−H arylations by oxazoline assistance. The broadly applicable, low‐valent cobalt catalyst displayed a wide substrate scope, and even proved applicable to challenging C−H alkylations with β‐hydrogen‐containing primary and secondary alkyl chlorides. The power of the cobalt‐catalyzed C−H arylation protocol was among others reflected by facile C−H activation at a room temperature of 23 °C, and efficient late‐stage diversification, providing access to bioactive biaryls. Abstract :