Classification of proteins with shared motifs and internal repeats in the ECOD database. (21st February 2016)

• Record Type: Journal Article
• Authors: Schaeffer, R. Dustin; Kinch, Lisa N.; Liao, Yuxing; Grishin, Nick V.
• Other Names: Bolon Dan guestEditor.; Baker David guestEditor.; Tawfik Dan guestEditor.
• Is Part Of: Protein science. Volume 25:Number 7(2016:Jul.)
• Page Start: 1188
• Page End: 1203
• Publication Date: 2016-02-21
• Subjects: structural bioinformatics -- protein classification -- protein motifs -- internal -- repeats -- structural genomics; Proteins -- Periodicals; 572.6
• DOI: 10.1002/pro.2893
• Languages: English
• ISSNs: 0961-8368

Abstract

Abstract: Proteins and their domains evolve by a set of events commonly including the duplication and divergence of small motifs. The presence of short repetitive regions in domains has generally constituted a difficult case for structural domain classifications and their hierarchies. We developed the Evolutionary Classification Of protein Domains (ECOD) in part to implement a new schema for the classification of these types of proteins. Here we document the ways in which ECOD classifies proteins with small internal repeats, widespread functional motifs, and assemblies of small domain‐like fragments in its evolutionary schema. We illustrate the ways in which the structural genomics project impacted the classification and characterization of new structural domains and sequence families over the decade.