A short bout of HFD promotes long-lasting hepatic lipid accumulation. (3rd February 2016)

• Record Type: Journal Article
• Authors: Chiazza, Fausto; Challa, Tenagne D; Lucchini, Fabrizio C; Konrad, Daniel; Wueest, Stephan
• Is Part Of: Adipocyte. Volume 5:Number 1(2016)
• Page Start: 88
• Page End: 92
• Publication Date: 2016-02-03
• Subjects: diabetes mellitus -- insulin resistance -- liver -- portal hypothesis -- steatosis; Fat cells -- Periodicals; Adipocytes -- Periodicals; 611.018276
• DOI: 10.1080/21623945.2015.1071454
• Languages: English
• ISSNs: 2162-3945

Abstract

Abstract: A short bout of high fat diet (HFD) impairs glucose tolerance and induces hepatic steatosis in mice. Here, we aimed to elaborate on long-lasting effects of short-term high fat feeding. As expected, one week of HFD significantly impaired glucose tolerance. Intriguingly, recovery feeding with a standard rodent diet for 8 weeks did not fully normalize glucose tolerance. In addition, mice exposed to a short bout of HFD revealed significantly increased liver fat accumulation paralleled by elevated portal free fatty acid levels after 8 weeks of recovery feeding compared to exclusively chow-fed littermates. In conclusion, a short bout of HFD has long-lasting effects on hepatic lipid accumulation and glucose tolerance.