Antimalarial and Antioxidant Activities of Isoprenylated Coumarins from the Stem Bark of Mesua borneensis L. Issue 2 (3rd March 2016)

• Record Type: Journal Article
• Authors: Tanjung, Mulyadi; Saputri, Ratih Dewi; Fitriati, Faiz Fakhriah; Tjahjandarie, Tjitjik Srie
• Is Part Of: Journal of biologically active products from nature. Volume 6:Issue 2(2016)
• Page Start: 95
• Page End: 100
• Publication Date: 2016-03-03
• Subjects: Isoprenylated coumarin -- Mesua borneensis L -- Antimalarial -- Antioxidant; Natural products -- Periodicals; Biological products -- Periodicals; 660.6
• DOI: 10.1080/22311866.2016.1188726
• Languages: English
• ISSNs: 2231-1866

Abstract

Abstract: The aim of this study was to assess the antimalarial and antioxidant effects of the n -hexane and ethyl acetate extracts together with three isolated isoprenylated coumarins, mammea A/BA(1 ), mammea A/ AA cyclo D(2) and mesuol(3) from the stem bark of M. borneensis L . The n -hexane and ethyl acetate extracts, as well as compounds1-3 were evaluated for their antimalarial activity against Plasmodium falciparum strain 3D7 (chloroquine-sensitive) and their antioxidant activity against DPPH radical scavenging. Compound2 exhibited slightly more active than chloroquine. Compounds1 and3 showed very high activity against DPPH radical.