SOD1 gene polymorphisms in sudden sensorineural hearing loss. (3rd May 2016)
- Record Type:
- Journal Article
- Title:
- SOD1 gene polymorphisms in sudden sensorineural hearing loss. (3rd May 2016)
- Main Title:
- SOD1 gene polymorphisms in sudden sensorineural hearing loss
- Authors:
- Kitoh, Ryosuke
Nishio, Shin-Ya
Ogawa, Kaoru
Okamoto, Makito
Kitamura, Ken
Gyo, Kiyofumi
Sato, Hiroaki
Nakashima, Tsutomu
Fukuda, Satoshi
Fukushima, Kunihiro
Hara, Akira
Yamasoba, Tatsuya
Usami, Shin-ichi - Abstract:
- Abstract: Conclusion The results suggest that SOD1 rs4998557 could be associated with susceptibility to SSNHL in the Japanese population.Objectives To assess the gene association with sudden sensorineural hearing loss (SSNHL).Methods A two-stage case control study was conducted to explore the relationship of the candidate genes to SSNHL. The 192 gene samples from SSNHL patients registered in the intractable inner ear disease gene bank were enrolled. As the candidate genes, 39 SNPs from 31 genes were selected for the first stage study. The second stage study examined whether the SOD1 gene polymorphisms, defined by significant differences between cases and controls in the first stage study, are associated with SSNHL.Results Significant differences were observed in four SNPs from three genes, Glutathione-S-transferase pai 1 (GSTP1), proteine kinase C heta (PRKCH), and superoxide dismutase 1 (SOD1), in terms of allele frequency between SSNHL patients and HapMap controls. In the SOD1 gene, a significant difference was observed in the dominant model study of the SNP rs4998557 in the second stage study. Furthermore, as a result of dividing SSNHL patients based on the clinical data, the difference was more apparent in the case of the over 60 dB group and the tinnitus–positive group.
- Is Part Of:
- Acta oto-laryngologica. Volume 136:Number 5(2016)
- Journal:
- Acta oto-laryngologica
- Issue:
- Volume 136:Number 5(2016)
- Issue Display:
- Volume 136, Issue 5 (2016)
- Year:
- 2016
- Volume:
- 136
- Issue:
- 5
- Issue Sort Value:
- 2016-0136-0005-0000
- Page Start:
- 465
- Page End:
- 469
- Publication Date:
- 2016-05-03
- Subjects:
- Allele frequency -- candidate gene -- clinical data -- dominant model -- gene bank
Otolaryngology -- Periodicals
Ear -- Diseases -- Periodicals
Throat -- Diseases -- Periodicals
Otolaryngology -- Electronic Resources
Otorhinolaryngologic Diseases
617.8 - Journal URLs:
- http://www.tandfonline.com/loi/ioto20#.V6CqjFJTHcs ↗
http://informahealthcare.com ↗ - DOI:
- 10.3109/00016489.2015.1116047 ↗
- Languages:
- English
- ISSNs:
- 0001-6489
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 0642.250000
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