Genetic polymorphisms in MMP 2, 3 and 9 genes and the susceptibility of osteosarcoma in a Chinese Han population. (17th February 2016)

• Record Type: Journal Article
• Authors: Cui, Yan; Zhu, Jia-Jun; Ma, Cheng-bin; Cui, Kai; Wang, Feng; Ni, Sheng-Hui; Zhang, Zhi-Yu
• Is Part Of: Biomarkers. Volume 21:Number 2(2016)
• Page Start: 160
• Page End: 163
• Publication Date: 2016-02-17
• Subjects: MMPs -- osteosarcoma -- single-nucleotide polymorphism -- susceptibility; Biochemical markers -- Periodicals; 610.28
• DOI: 10.3109/1354750X.2015.1118550
• Languages: English
• ISSNs: 1354-750X

Abstract

Abstract: Background : There are no data about the role of MMPs polymorphism in development of osteosarcoma. Patients and methods : Two-hundred fifty-one patients with osteosarcoma and 251 healthy controls were included to investigate the association between the MMP2, 3, 9 polymorphisms and the risk of osteosarcoma. Results : Compared with the MMP 2 SNP rs243865 homozygote CC, The heterozygous CT genotype was associated with significantly increased risk for osteosarcoma (OR = 1.86, 95% CI = 1.18–4.22, p = 0.014); the TT genotype was associated with increased risk for osteosarcoma (OR = 1.92, 95% CI = 1.21–3.52, p = 0.028). However, the genotype and allele frequencies of MMP 3 rs3025058 and MMP 9 rs3918242 polymorphisms were not significantly different. Conclusion : MMP 2 rs243865 genotype was associated with increased risk for development of osteosarcoma in Chinese Han population.