Invasive pneumococcal disease leads to activation and hyperreactivity of platelets. Issue 144 (August 2016)

• Record Type: Journal Article
• Authors: Tunjungputri, Rahajeng N.; de Jonge, Marien I.; de Greeff, Astrid; van Selm, Saskia; Buys, Herma; Harders-Westerveen, Jose F.; Stockhofe-Zurwieden, Norbert; Urbanus, Rolf T.; de Groot, Phillip G.; Smith, Hilde E.; van der Ven, Andre J.; de Mast, Quirijn
• Is Part Of: Thrombosis research. Issue 144(2016)
• Page Start: 123
• Page End: 126
• Publication Date: 2016-08
• Subjects: Platelets -- Pneumonia -- Streptococcus pneumoniae -- Myocardial infarction -- Platelet activation -- Infection; Thrombosis -- Periodicals; 616.135
• DOI: 10.1016/j.thromres.2016.06.016
• Languages: English
• ISSNs: 0049-3848

Abstract

Abstract: Using a novel porcine model of intravenous Streptococcus pneumoniae infection, we showed that invasive pneumococcal infections induce marked platelet activation and hyperreactivity. This may contribute to the vascular complications seen in pneumococcal infection.