Autoimmune pancreatitis and inflammatory bowel disease: Case series and review of the literature. Issue 8 (August 2016)

• Record Type: Journal Article
• Authors: Roque Ramos, Lídia; DiMaio, Christopher J.; Sachar, David B.; Atreja, Ashish; Colombel, Jean-Frédéric; Torres, Joana
• Is Part Of: Digestive and liver disease. Volume 48:Issue 8(2016)
• Page Start: 893
• Page End: 898
• Publication Date: 2016-08
• Subjects: Autoimmune pancreatitis -- Idiopathic duct-centric pancreatitis -- Inflammatory bowel disease -- Lymphoplasmacytic sclerosing pancreatitis; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; 616.33005
• DOI: 10.1016/j.dld.2016.05.008
• Languages: English
• ISSNs: 1590-8658

Abstract

Abstract: Background: An association between autoimmune pancreatitis (AIP) and inflammatory bowel disease (IBD) has been documented, but its clinical significance remains unclear. Aims: Characterize the particular phenotypes of IBD and AIP in patients with both diseases (IBD-AIP). Methods: Retrospective study of patients with IBD-AIP followed at our IBD referral centre and literature search to identify previous reports of IBD-AIP patients. Results: We found 5 cases of IBD-AIP in our records and 5 prior studies reporting 47 additional IBD-AIP patients. A combined analysis showed that most IBD-AIP patients were young males with ulcerative colitis, usually extensive, and that in all Crohn's disease cases, the colon was involved. IBD severity was heterogeneous across studies, ranging from mild disease to severe disease requiring colectomy. The most frequent type of AIP was idiopathic duct-centric pancreatitis (type 2) and it most often occurred after the diagnosis of IBD. AIP presentation and treatment were similar to those in the general population. Conclusions: AIP occurs rarely with IBD; in the other way around, up to 1/3 of AIP patients, especially type 2, may have concomitant IBD. IBD-AIP patients are usually males presenting extensive colitis. More data are needed on the impact of AIP, if any, in IBD course.