Association of the microsatellite (GT)n repeat polymorphisms of the HO-1 gene promoter and corresponding serum levels with the risk of laryngeal squamous cell carcinoma. (2nd August 2016)

• Record Type: Journal Article
• Authors: Tang, Di; Tang, Wei-Jing; Shi, Xiao-Ling; Li, Wen-Ping; Zhou, Hong; Lu, Li-Ming; Tao, Lei
• Is Part Of: Acta oto-laryngologica. Volume 136:Number 8(2016)
• Page Start: 806
• Page End: 811
• Publication Date: 2016-08-02
• Subjects: Heme oxygenase-1 -- polymorphism -- serum -- laryngeal squamous cell carcinoma -- vocal cord leukoplakia; Otolaryngology -- Periodicals; Ear -- Diseases -- Periodicals; Throat -- Diseases -- Periodicals; Otolaryngology -- Electronic Resources; Otorhinolaryngologic Diseases; 617.8
• DOI: 10.3109/00016489.2016.1157265
• Languages: English
• ISSNs: 0001-6489

Abstract

Abstract: Conclusion : Long (GT)n repeat polymorphisms in the heme oxygenase-1 (HO-1) gene promoter and decreased serum HO-1 levels are associated with a higher susceptibility to laryngeal squamous cell carcinoma (LSCC).Objective : In this case-control study, the association of HO-1 microsatellite (GT)n repeat polymorphisms and serum levels with the risk of LSCC was investigated.Methods : A total of 142 LSCC patients, 54 vocal leukoplakia patients and 98 healthy controls, were examined for (GT)n polymorphisms by sequencing, and the serum HO-1 levels were detected in a sub-set from participants above by ELISA.Results : Compared with the controls, the LSCC group had significantly higher frequencies of L-allele (> 29 repeats) and L-allele carriers ( p < 0.001, OR = 2.037 and p = 0.005, OR = 2.152, respectively). The frequencies of lymph node metastasis and of moderate or poor differentiation were significantly higher in L-allele carriers compared to non-L-allele carriers ( p < 0.05). Significantly lower serum HO-1 levels were detected in LSCC patients ( p < 0.001), and patients with lower serum HO-1 levels had more advanced cancer stage and a higher lymph node metastasis rate ( p < 0.05). Furthermore, the L-allele carriers had lower serum HO-1 concentrations compared with the non-L-allele carriers ( p = 0.019).