DNA Origami: Folded DNA‐Nanodevices That Can Direct and Interpret Cell Behavior. Issue 27 (3rd February 2016)

• Record Type: Journal Article
• Authors: Kearney, Cathal J.; Lucas, Christopher R.; O'Brien, Fergal J.; Castro, Carlos E.
• Is Part Of: Advanced materials. Volume 28:Issue 27(2016)
• Page Start: 5509
• Page End: 5524
• Publication Date: 2016-02-03
• Subjects: biosensing -- DNA origami -- drug delivery -- nanoparticles -- nanopores; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201504733
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : DNA origami is a DNA‐based nanotechnology that utilizes programmed combinations of short complementary oligonucleotides to fold a large single strand of DNA into precise 2D and 3D shapes. The exquisite nanoscale shape control of this inherently biocompatible material is combined with the potential to spatially address the origami structures with diverse cargoes including drugs, antibodies, nucleic acid sequences, small molecules, and inorganic particles. This programmable flexibility enables the fabrication of precise nanoscale devices that have already shown great potential for biomedical applications such as: drug delivery, biosensing, and synthetic nanopore formation. Here, the advances in the DNA‐origami field since its inception several years ago are reviewed with a focus on how these DNA‐nanodevices can be designed to interact with cells to direct or probe their behavior. Abstract : DNA origami can exploit the natural spatial addressability of DNA to create precise nanoscale shapes that can carry cargoes. This flexible design potential makes it an excellent candidate to direct or probe cell behavior. Here, the history and design principles of DNA origami and the recent advances and future challenges for these structures in biomedical applications including drug delivery are described.