Nanoscale Engineering of Designer Cellulosomes. Issue 27 (7th January 2016)

• Record Type: Journal Article
• Authors: Gunnoo, Melissabye; Cazade, Pierre‐André; Galera‐Prat, Albert; Nash, Michael A.; Czjzek, Mirjam; Cieplak, Marek; Alvarez, Beatriz; Aguilar, Marina; Karpol, Alon; Gaub, Hermann; Carrión‐Vázquez, Mariano; Bayer, Edward A.; Thompson, Damien
• Is Part Of: Advanced materials. Volume 28:Issue 27(2016)
• Page Start: 5619
• Page End: 5647
• Publication Date: 2016-01-07
• Subjects: materials modeling -- molecular dynamics calculations -- nanobiomaterials -- protein re‐engineering -- renewable energy; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201503948
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : Biocatalysts showcase the upper limit obtainable for high‐speed molecular processing and transformation. Efforts to engineer functionality in synthetic nanostructured materials are guided by the increasing knowledge of evolving architectures, which enable controlled molecular motion and precise molecular recognition. The cellulosome is a biological nanomachine, which, as a fundamental component of the plant‐digestion machinery from bacterial cells, has a key potential role in the successful development of environmentally‐friendly processes to produce biofuels and fine chemicals from the breakdown of biomass waste. Here, the progress toward so‐called "designer cellulosomes", which provide an elegant alternative to enzyme cocktails for lignocellulose breakdown, is reviewed. Particular attention is paid to rational design via computational modeling coupled with nanoscale characterization and engineering tools. Remaining challenges and potential routes to industrial application are put forward. Abstract : Recent progress toward the realization of designer cellulosomes is reviewed. These biological nanomaterials have the potential to produce clean, renewable feedstocks for production of biofuels and fine chemicals from the breakdown of biomass waste. Insights gleaned from nanoscale characterization and modeling of these engineered architectures provide inspiration for design of advanced materials with unprecedented control of molecular‐level materials processing in complex environments.