Superfluorinated PEI Derivative Coupled with 99mTc for ASGPR Targeted 19F MRI/SPECT/PA Tri‐Modality Imaging. Issue 28 (9th May 2016)

• Record Type: Journal Article
• Authors: Guo, Zhide; Gao, Mengna; Song, Manli; Li, Yesen; Zhang, Deliang; Xu, Duo; You, Linyi; Wang, Liangliang; Zhuang, Rongqiang; Su, Xinhui; Liu, Ting; Du, Jin; Zhang, Xianzhong
• Is Part Of: Advanced materials. Volume 28:Issue 28(2016)
• Page Start: 5898
• Page End: 5906
• Publication Date: 2016-05-09
• Subjects: 19F magnetic resonance imaging -- liver function -- molecular imaging -- photoacoustic imaging -- single‐photon‐emission computed tomography; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201601064
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : Fluorinated polyethylenimine derivative labeled with radionuclide 99m Tc is developed as a 19 F MRI/SPECT/PA multifunctional imaging agent with good asialoglycoprotein receptors (ASGPR)‐targeting ability. This multifunctional agent is safe and suitable for 19 F MRI/SPECT/PA imaging and has the potential to detect hepatic diseases and to assess liver function, which provide powerful support for the development of personalized and precision medicine.