An Improved Catalyst for Iodine(I/III)‐Catalysed Intermolecular CH Amination. Issue 13 (31st March 2016)

• Record Type: Journal Article
• Authors: Lucchetti, Nicola; Scalone, Michelangelo; Fantasia, Serena; Muñiz, Kilian
• Is Part Of: Advanced synthesis & catalysis. Volume 358:Issue 13(2016)
• Page Start: 2093
• Page End: 2099
• Publication Date: 2016-03-31
• Subjects: amination -- arenes -- CH functionalization -- catalysis -- hypervalent iodine; Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201600191
• Languages: English
• ISSNs: 1615-4150

Abstract

Abstract: 1, 2‐Diiodobenzene is presented as an efficient catalyst precursor for the intermolecular amination of arenes under homogeneous conditions. N ‐Troc‐ and N ‐phthalimido‐substituted methoxyamines serve as suitable nitrogen sources providing the corresponding aniline derivatives in up to 99% yield and with up to 66:1 regioselectivity. Key for this successful CN coupling protocol is the strained μ‐oxo‐bridged conformation of the bisiodine(III) catalyst, which induces unparalleled high reactivity. Abstract :