Emerging Diversity of the Cobalamin‐Dependent Methyltransferases Involving Radical‐Based Mechanisms. (23rd April 2016)

• Record Type: Journal Article
• Authors: Ding, Wei; Li, Qien; Jia, Youli; Ji, Xinjian; Qianzhu, Haocheng; Zhang, Qi
• Is Part Of: Chembiochem. Volume 17:Number 13(2016)
• Page Start: 1191
• Page End: 1197
• Publication Date: 2016-04-23
• Subjects: biosynthesis -- cobalamins -- methyltransferases -- radical SAM -- vitamin B12; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201600107
• Languages: English
• ISSNs: 1439-4227

Abstract

Abstract: Cobalamins comprise a group of cobalt‐containing organometallic cofactors that play important roles in cellular metabolism. Although many cobalamin‐dependent methyltransferases (e.g., methionine synthase MetH) have been extensively studied, a new group of methyltransferases that are cobalamin‐dependent and utilize radical chemistry in catalysis is just beginning to be appreciated. In this Concept article, we summarize recent advances in the understanding of the radical‐based and cobalamin‐dependent methyltransferases and discuss the functional and mechanistic diversity of this emerging class of enzymes. Abstract : A radical approach : Although many cobalamin‐dependent methyltransferases have been extensively investigated, a new group of these compounds that utilizes radical chemistry is just beginning to be appreciated. The functional and mechanistic diversity of this emerging class of enzymes is discussed in detail in this Concept article.