Enhancing Tumor Cell Response to Chemotherapy through the Targeted Delivery of Platinum Drugs Mediated by Highly Stable, Multifunctional Carboxymethylcellulose‐Coated Magnetic Nanoparticles. Issue 28 (1st June 2016)

• Record Type: Journal Article
• Authors: Medříková, Zdenka; Novohradsky, Vojtech; Zajac, Juraj; Vrána, Oldřich; Kasparkova, Jana; Bakandritsos, Aristides; Petr, Martin; Zbořil, Radek; Brabec, Viktor
• Is Part Of: Chemistry. Volume 22:Issue 28(2016)
• Page Start: 9750
• Page End: 9759
• Publication Date: 2016-06-01
• Subjects: cytotoxicity -- drug delivery -- magnetic properties -- nanoparticles -- platinum; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201600949
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: The fabrication of nanoparticles using different formulations, and which can be used for the delivery of chemotherapeutics, has recently attracted considerable attention. We describe herein an innovative approach that may ultimately allow for the selective delivery of anticancer drugs to tumor cells by using an external magnet. A conventional antitumor drug, cisplatin, has been incorporated into new carboxymethylcellulose‐stabilized magnetite nanoparticles conjugated with the fluorescent marker Alexa Fluor 488 or folic acid as targeting agent. The magnetic nanocarriers possess exceptionally high biocompatibility and colloidal stability. These cisplatin‐loaded nanoparticles overcome the resistance mechanisms typical of free cisplatin. Moreover, experiments aimed at the localization of the nanoparticles driven by an external magnet in a medium that mimics physiological conditions confirmed that this localization can inhibit tumor cell growth site‐specifically. Abstract : Targeted chemotherapy : Multifunctional magnetically driven nanoparticles stabilized with carboxymethylcellulose (cMNPs) show promise in improving the therapeutic index of anticancer agents. The complexation of cisplatin to cMNPs has a favorable influence on the toxic and selective effects cisplatin on cancer cells. These cMNPs can be controlled and moved with an external magnetic field, thereby allowing drug release at a specific area.