Supramolecular Antibiotic Switches: A Potential Strategy for Combating Drug Resistance. Issue 32 (17th June 2016)

• Record Type: Journal Article
• Authors: Bai, Haotian; Lv, Fengting; Liu, Libing; Wang, Shu
• Is Part Of: Chemistry. Volume 22:Issue 32(2016)
• Page Start: 11114
• Page End: 11121
• Publication Date: 2016-06-17
• Subjects: antibiotics -- drug resistance -- host–guest systems -- photochemical switches -- supramolecular chemistry; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201600877
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: Bacterial infectious disease is a serious public health concern throughout the world. Pathogen drug resistance, arising from both rational use and abuse/misuse of germicides, complicates the situation. Aside from developing novel antibiotics and antimicrobial agents, molecular approaches have become another significant method to overcome the problem of pathogen drug resistance. Established supramolecular systems, the antibiotic properties of which can be switched "on" and "off" through host–guest interactions, show great potential in combating issues regarding antibiotic resistance in the long term, as indicated by several recent studies. In this Concept, recently developed strategies for antibacterial regulation are summarized and further directions for research into antibiotic switches are proposed. Abstract : 99 problems but a switch ain't one : Bacterial infectious disease is a serious public health concern throughout the world. Supramolecular antibiotic systems that can be switched "on" and "off" through host–guest interactions show great potential in combating issues regarding antibiotic resistance in the long term. In this Concept, recently developed strategies for antibacterial regulation are summarized and further research directions are proposed.