Hyperpolarization of Nitrogen‐15 Schiff Bases by Reversible Exchange Catalysis with para‐Hydrogen. Issue 31 (22nd June 2016)

• Record Type: Journal Article
• Authors: Logan, Angus W. J.; Theis, Thomas; Colell, Johannes F. P.; Warren, Warren S.; Malcolmson, Steven J.
• Is Part Of: Chemistry. Volume 22:Issue 31(2016)
• Page Start: 10777
• Page End: 10781
• Publication Date: 2016-06-22
• Subjects: amino acids -- homogeneous catalysis -- imaging agents -- iridium -- NMR spectroscopy; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201602393
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: NMR with thermal polarization requires relatively concentrated samples, particularly for nuclei with low abundance and low gyromagnetic ratios, such as 15 N. We expand the substrate scope of SABRE, a recently introduced hyperpolarization method, to allow access to 15 N‐enriched Schiff bases. These substrates show fractional 15 N polarization levels of up to 2 % while having only minimal 1 H enhancements. Abstract : Chemical Schifft : NMR with thermal polarization requires relatively concentrated samples, particularly for nuclei with low abundance and low gyromagnetic ratios, such as 15 N. 15 N Schiff bases (see scheme) have been demonstrated to be a new class of substrates effectively hyperpolarized by Signal Amplification by Reversible Exchange (SABRE).