The (6–4) Dimeric Lesion as a DNA Photosensitizer. Issue 13 (14th June 2016)

• Record Type: Journal Article
• Authors: Vendrell‐Criado, Victoria; Rodríguez‐Muñiz, Gemma M.; Lhiaubet‐Vallet, Virginie; Cuquerella, M. Consuelo; Miranda, Miguel A.
• Is Part Of: Chemphyschem. Volume 17:Issue 13(2016)
• Page Start: 1943
• Page End: 1943
• Publication Date: 2016-06-14
• Subjects: Chemistry, Physical and theoretical -- Periodicals; 541.05
• DOI: 10.1002/cphc.201600583
• Languages: English
• ISSNs: 1439-4235

Abstract

Abstract: The front cover artwork is provided by Miguel A. Miranda and co‐workers at Instituto de Tecnología Química (UPV‐CSIC). The image shows that (6–4) photoproducts, primary UVB dimeric lesions, act as photosensitizers of cyclobutane pyrimidine dimers that are produced as secondary DNA lesions. Read the full text of the article at10.1002/cphc.201600154 . Abstract : "The primary (6–4) dimeric DNA lesion acts as a photosensitizer, leading to the formation of secondary cyclobutane dimersor oxidative damage in its vicinity. This may be relevant in connection with the occurrence of "tandem" or clustered lesions, where several DNA modifications occur within a few base pairs.…" This and more about the story behind the front cover can be found in the Full Paper at10.1002/cphc.201600154 .