Nuclear protein in testis midline carcinoma of larynx: An underdiagnosed entity. Issue 8 (29th March 2016)

• Record Type: Journal Article
• Authors: Kundra, Ajay; Andrei, Mirela; Westra, William; Chaudhry, Rashid; Moussouris, Harry; Gohari, Arash; Wang, Jen C.
• Other Names: Irish Jonathan sponsoringEditor.
• Is Part Of: Head & neck. Volume 38:Issue 8(2016)
• Page Start: E2471
• Page End: E2474
• Publication Date: 2016-03-29
• Subjects: nuclear protein in testis (NUT) midline carcinoma -- laryngeal carcinoma; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.24418
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: Nuclear protein in testis (NUT) carcinomas are very rare and have a very poor survival rate. The most common sites of involvement include the nasal cavity, sinus, and mediastinum. Laryngeal NUT midline carcinoma is extremely rare, with only 2 cases reported thus far. Here, we are describing another case of NUT laryngeal carcinoma. Methods and Results: The patient was a light smoker and nondrinker who presented with upper respiratory tract obstruction. Imaging and laryngoscopic evaluation revealed a large intraluminal laryngeal mass. Biopsy demonstrated poorly differentiated carcinoma with intact mucosa and only focal coexpression of CK5/6 and p40. NUT protein immune‐stain positivity conclusively established the diagnosis of NUT midline carcinoma. Conclusion: Absence of well‐known risk factors, pathologic finding of lack of mucosal involvement and lack of squamous differentiation with poorly differentiated carcinoma, should prompt clinicians to consider this rare entity as a possible diagnosis. © 2016 Wiley Periodicals, Inc. Head Neck 38:E2471–E2474, 2016