Assisted 6‐minute cycling test: An exploratory study in children. Issue 2 (13th June 2016)

• Record Type: Journal Article
• Authors: Dirks, Ilse; Koene, Saskia; Verbruggen, Renee; Smeitink, Jan A.M.; Jansen, Merel; Groot, Imelda J.M. De
• Is Part Of: Muscle & nerve. Volume 54:Issue 2(2016)
• Page Start: 232
• Page End: 238
• Publication Date: 2016-06-13
• Subjects: assisted 6‐minute cycling test (A6MCT) -- 6‐minute walk test (6MWT) -- neuromuscular disorders -- OXHPOS dysfunction in muscle -- outcome measure; Neuromuscular diseases -- Periodicals; Muscles -- Periodicals; Nerves -- Periodicals; 616.74
• DOI: 10.1002/mus.25021
• Languages: English
• ISSNs: 0148-639X

Abstract

ABSTRACT: Introduction : The 6‐minute walk test (6MWT) is frequently used as an outcome measure for clinical trials in neuromuscular disease. Because this submaximal endurance test is not feasible for nonambulatory patients, the motor‐assisted 6‐minute cycling test (A6MCT) was developed. Methods : Nineteen children with neuromuscular disorders and children with OXPHOS‐dysfunction performed the a6MCT and the 6MWT to explore feasibility and construct validity. Test–retest reproducibility was evaluated within 3 weeks. Results : The assisted 6‐minute cycling test was feasible in 90% and 78% of the patients with a neuromuscular disorder and OXPHOS‐dysfunction, respectively. The A6MCT for legs correlated with the 6MWT in both patient groups. The assisted 6‐minute cycling showed good reproducibility for both legs and arms. Conclusions : This exploratory study indicates that the assisted 6‐minute cycling test is a promising outcome measure for patients with a neuromuscular disorder and patients with OXPHOS‐dysfunction. Muscle Nerve, 2015. Muscle Nerve 54 : 232–238, 2016