High‐Performance Upconversion Nanoprobes for Multimodal MR Imaging of Acute Ischemic Stroke. Issue 26 (24th May 2016)

• Record Type: Journal Article
• Authors: Wang, Jing; Zhang, Hua; Ni, Dalong; Fan, Wenpei; Qu, Jianxun; Liu, Yanyan; Jin, Yingying; Cui, Zhaowen; Xu, Tianyong; Wu, Yue; Bu, Wenbo; Yao, Zhenwei
• Is Part Of: Small. Volume 12:Issue 26(2016)
• Page Start: 3591
• Page End: 3600
• Publication Date: 2016-05-24
• Subjects: acute ischemic stroke -- MR angiography imaging -- medical imaging -- multimodal MR imaging -- PEG‐UCNP nanoparticles; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201601144
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : Multimodal magnetic resonance (MR) imaging, including MR angiography (MRA) and MR perfusion (MRP), plays a critical role in the diagnosis and surveillance of acute ischemic stroke. However, these techniques are hindered by the low T1 relaxivity, short circulation time, and high leakage rate from vessels of clinical Magnevist. To address these problems, nontoxic polyethylene glycol (PEG)ylated upconversion nanoprobes (PEG‐UCNPs) are synthesized and first adopted for excellent MRA and MRP imaging, featuring high diagnostic sensitivity toward acute ischemic stroke in high‐resolution imaging. The investigations show that the agent possesses superior advantages over clinical Magnevist, such as much higher relaxivity, longer circulation time, and lower leakage rate, which guarantee much better imaging efficiency. Remarkably, an extremely small dosage (5 mg Gd kg −1 ) of PEG‐UCNPs provides high‐resolution MRA imaging with the vascular system delineated much clearer than the Magnevist with clinical dosage as high as 108 mg Gd kg −1 . On the other hand, the long circulation time of PEG‐UCNPs enables the surveillance of the progression of ischemic stroke using MRA or MRP. Once translated, these PEG‐UCNPs are expected to be a promising candidate for substituting the clinical Magnevist in MRA and MRP, which will significantly lengthen the imaging time window and improve the overall diagnostic efficiency. Abstract : High‐performance polyethylene glycol (PEG)‐ylated upconversion nanoprobes (PEG‐UCNP nanoprobes) synthesized through the typical thermal decomposition method are successfully used for multimodal magnetic resonance (MR) imaging including MR angiography and MR perfusion imaging, which possess distinctive advantages compared with clinical Magnevist on the vascular system imaging and the diagnosis of acute ischemic stroke.