Silica Nanospheres: Hollow Structure Improved Anti‐Cancer Immunity of Mesoporous Silica Nanospheres In Vivo (Small 26/2016). Issue 26 (7th July 2016)

• Record Type: Journal Article
• Authors: Wang, Xiupeng; Li, Xia; Ito, Atsuo; Yoshiyuki, Kazuko; Sogo, Yu; Watanabe, Yohei; Yamazaki, Atsushi; Ohno, Tadao; Tsuji, Noriko M.
• Is Part Of: Small. Volume 12:Issue 26(2016)
• Page Start: 3602
• Page End: 3602
• Publication Date: 2016-07-07
• Subjects: cancer immunoadjuvant -- hollow structures -- mesoporous silica nanospheres; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.201670129
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract : Hollow and non‐hollow mesoporous silica nanospheres are synthesized and used for cancer vaccine adjuvants by X. Wang, A. Ito, N. M. Tsuji, and co‐workers on page 3510. The hollow structure of mesoporous silica nanospheres significantly promotes cellular uptake of a model cancer antigen by macrophage‐like cells in vitro, improves anti‐cancer immunity, and increases CD4+ and CD8+ T cell populations in splenocytes of mice in vivo.