Development and characterization of floating spheroids of atorvastatin calcium loaded NLC for enhancement of oral bioavailability. (17th August 2016)

• Record Type: Journal Article
• Authors: Sharma, Kritika; Hallan, Supandeep Singh; Lal, Bharat; Bhardwaj, Ankur; Mishra, Neeraj
• Is Part Of: Artificial cells, nanomedicine, and biotechnology. Volume 44:Number 6(2016)
• Page Start: 1448
• Page End: 1456
• Publication Date: 2016-08-17
• Subjects: floating spheroids -- hyperlipidemia -- nanostructured lipid carriers (NLCs) -- oral bioavailability; Artificial cells -- Periodicals; Nanotechnology -- Periodicals; Blood substitutes -- Periodicals; Tissue engineering -- Periodicals; Molecules -- Periodicals; Biotechnology -- Periodicals; 615.39
• DOI: 10.3109/21691401.2015.1041637
• Languages: English
• ISSNs: 2169-1401

Abstract

Abstract : Objective: The obejctive of the present study was to investigate the potential use of floating spheroids of Atorvastatin Calcium (ATS) Loaded nanostructured lipid carriers (NLCs). Materials and Methods: The final formula of floating spheroids was optimized on the basis of shape (spherical), diameter (0.47 mm), lag time (20 s), and floating time (> 32 h). Results: The results were further confirmed by different pharmacokinetic parameters—it was observed that the developed optimized floating ATS spheroid-loaded NLCs formulation has significantly improved relative bioavailability, that is, 3.053-folds through oral route in comparison to marketed formulation.