ChemInform Abstract: A Concise One‐Pot Organo‐ and Biocatalyzed Preparation of Enantiopure Hexahydrofuro[2, 3‐b]furan‐3‐ol: An Approach to the Synthesis of HIV Protease Inhibitors. Issue 34 (4th August 2016)

• Record Type: Journal Article
• Authors: Kanemitsu, Takuya; Inoue, Mizuho; Yoshimura, Nono; Yoneyama, Kazutoshi; Watarai, Rie; Miyazaki, Michiko; Odanaka, Yuki; Nagata, Kazuhiro; Itoh, Takashi
• Is Part Of: ChemInform. Volume 47:Issue 34(2016)
• Page Start: no
• Page End: no
• Publication Date: 2016-08-04
• Subjects: furan derivatives -- ring closure reactions, annulation reactions -- organocatalysis -- biochemical syntheses, microbiological syntheses -- pharmacology, medicinal chemistry, vaccines, serums; Chemistry -- Abstracts -- Periodicals; 540.5
• DOI: 10.1002/chin.201634106
• Languages: English
• ISSNs: 0931-7597

Abstract

Abstract: The one‐pot synthesis of the title species (IV) involves condensation of dihydrofuran with glycolaldehyde dimer (II) followed by lipase‐catalyzed kinetic resolution.