Modulating role of pheromonal cues from oestrus‐specific urine on 3‐methylcholanthrene‐induced male reproductive toxicity. (29th December 2015)

• Record Type: Journal Article
• Authors: Suriyakalaa, U.; Gayathiri, R.; SankarGanesh, D.; Kokilavani, P.; Sukirtha, R.; Ramachandran, R.; Kamalakkannan, S.; Achiraman, S.
• Is Part Of: Andrologia. Volume 48:Number 7(2016)
• Page Start: 745
• Page End: 753
• Publication Date: 2015-12-29
• Subjects: 3‐Methylcholanthrene -- endocrine disruptors -- oestrus‐specific urine -- pheromones -- testosterone; Andrology -- Periodicals; Infertility, Male -- Periodicals; 616.69
• DOI: 10.1111/and.12505
• Languages: English
• ISSNs: 0303-4569

Abstract

Summary: Polyaromatic hydrocarbons (PAHs) are persistent organic pollutants that contribute to endocrine/gonadal disruption. This study was designed to investigate the endocrine modulating role of pheromones in alleviating the reproductive toxic effects of 3‐MC (3‐methylcholanthrene), one of the common PAHs, in rat model. The rats were injected intraperitoneally with 3‐MC at a dose of 25 mg kg −1 BW. The serum levels of testosterone and other biochemical parameters were altered to significant levels in 3‐MC‐treated rats and oestrus‐specific urine exposure restored all these effects to near normal. Although testis weight did not indicate any significant change, sperm and spermatid counts were significantly reduced in 3‐MC‐treated rats, which became normal in oestrus‐urine‐exposed rats. Hence, this study suggests that oestrus‐specific urinary pheromones have the potential to modulate the endocrine system and alleviate the male reproductive toxic effects produced by 3‐MC.