Front Cover: Wide‐field time‐gated photoluminescence microscopy for fast ultrahigh‐sensitivity imaging of photoluminescent probes (J. Biophotonics 8/2016). Issue 8 (2nd August 2016)

• Record Type: Journal Article
• Authors: Razali, Wan A. W.; Sreenivasan, Varun K. A.; Bradac, Carlo; Connor, Mark; Goldys, Ewa M.; Zvyagin, Andrei V.
• Other Names: Vitkin Alex guestEditor.; Kirillin Mikhail guestEditor.; Zagaynova Elena guestEditor.
• Is Part Of: Journal of biophotonics. Volume 9:Issue 8(2016)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2016-08-02
• Subjects: Photonics -- Periodicals; Optical materials -- Periodicals; Optics -- Periodicals; Medical instruments and apparatus -- Periodicals; 621.3605
• DOI: 10.1002/jbio.201670080
• Languages: English
• ISSNs: 1864-063X

Abstract

Abstract : The ultimate limit of an imaging system based on photoluminescent molecular‐probes is set by the signal‐tonoise ratio between the bio‐probes and the background. A microscopy technique which combines nanoruby photoluminescent bio‐probes and time‐gating acquisition is proposed in order to achieve manifold improvement on imaging contrast capabilities. The system is sensitive and fast enough to image single nanoruby particles within cultured cells as well as to capture the particle‐binding kinetics in biological fluids. Further details can be found in the article by Wan A. W. Razali et al. on pp.848–858 .