A multifunctional nanoplatform for lysosome targeted delivery of nitric oxide and photothermal therapy under 808 nm near-infrared light. Issue 27 (22nd June 2016)

• Record Type: Journal Article
• Authors: Xiang, Hui-Jing; Guo, Min; An, Lu; Yang, Shi-Ping; Zhang, Qian-Ling; Liu, Jin-Gang
• Is Part Of: Journal of materials chemistry. Volume 4:Issue 27(2016)
• Page Start: 4667
• Page End: 4674
• Publication Date: 2016-06-22
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c6tb00730a
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : NIR light induced spatiotemporal delivery of NO to lysosome accompanied by hyperthermia was realized. Abstract : Nitric oxide (NO) plays important roles in various physiological and pathological processes. The development of multifunctional nanoplatforms that enable site-specific delivery of NO is expected to provide new insights toward the realization of NO-mediated therapy. We report herein a novel nanoplatform {Lyso-Ru-NO@FA@CDs}, (1 ), where a lysosome-targeting NO donor, Lyso-Ru-NO, and a folic-acid (FA)-directing group were incorporated into carbon dots (CDs). Nanoplatform1 exhibited immediate NO release and a rapid temperature increase when irradiated using an 808 nm laser. This nanoplatform was capable of targeting folate-receptor-positive cancer cell lines and specifically accumulated in the subcellular lysosomal organelle. The dual-targeted nanoplatform1 exhibited high cytotoxicity toward cancer cells under irradiation with 808 nm light, demonstrating substantially enhanced efficacy compared with its nontargeted counterparts. NIR-light-controlled spatiotemporal delivery of NO to targeted sites accompanied by photothermal therapy offers new possibilities for NO-involved multimodal cancer treatment.