A new more atom-efficient multi-component approach to tetrasubstituted imidazoles: one-pot condensation of nitriles, amines and benzoin. Issue 71 (15th July 2016)

• Record Type: Journal Article
• Authors: Khalafi-Nezhad, Ali; Shekouhy, Mohsen; Sharghi, Hashem; Aboonajmi, Jasem; Zare, Abdolkarim
• Is Part Of: RSC advances. Volume 6:Issue 71(2016)
• Page Start: 67281
• Page End: 67289
• Publication Date: 2016-07-15
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra11171h
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A new more atom-efficient multi-component approach for the synthesis of tetrasubstituted imidazoles via the one-pot condensation of nitriles, primary amines and benzoin has been described. Abstract : A new more atom-efficient multi-component approach for the synthesis of tetrasubstituted imidazoles via the one-pot condensation of nitriles, primary amines and benzoin has been described. Using this method, a wide range of structurally diverse nitriles and primary amines were successfully condensed with benzoin in glycerol in the presence of TFA under microwave irradiation at 120 °C and all the products were obtained in good to excellent yields with higher atom efficiencies in comparison with the commonly used four-component condensation of aldehydes, ammonium acetate, primary amines and benzil.