A metal-catalyzed enyne-cyclization step for the synthesis of bi- and tricyclic scaffolds amenable to molecular library production. Issue 29 (30th June 2016)

• Record Type: Journal Article
• Authors: Wu, Peng; Petersen, Michael Åxman; Cohrt, A. Emil; Petersen, Rico; Morgentin, Rémy; Lemoine, Hugues; Roche, Carine; Willaume, Anthony; Clausen, Mads H.; Nielsen, Thomas E.
• Is Part Of: Organic & biomolecular chemistry. Volume 14:Issue 29(2016)
• Page Start: 6947
• Page End: 6950
• Publication Date: 2016-06-30
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c6ob01148a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : A facile metal-catalyzed diversification step for the synthesis of novel bi- and tricyclic scaffolds from enyne substrates is reported in this study for molecular library production. Abstract : A facile metal-catalyzed diversification step for the synthesis of novel bi- and tricyclic scaffolds from enyne substrates is reported in this study. From a single starting material, topologically diverse scaffolds for library synthesis can be generated and decorated in a few steps. The methodology was used to produce a library of 490 compounds within the European Lead Factory (ELF) Consortium.