Highly solvatochromic and tunable fluorophores based on a 4, 5-quinolimide scaffold: novel CDK5 probes12. Issue 62 (7th July 2016) - González-Vera, Juan A.
Abstract : Novel 4, 5-quinolimide-based solvatochromic fluorophores conjugated to a CDK5 derived peptide demonstrated sensitivity for monitoring CDK5/p25 interaction in living cells. Abstract : Novel 4, 5-quinolimide-based fluorophores are more solvatochromic and red-shifted than known naphthalimide analogues. Conjugation of one of these fluorophores to a peptide derived from CDK5 kinase demonstrated its sensitivity for monitoring the interaction with its regulatory partner p25. Introduction of the quinolimide-labelled peptide into living glioblastoma cells probed the interaction with endogenous p25.