Unusual seeding effect in the liquid-assisted high-pressure polymorphism of chlorpropamide. Issue 29 (16th June 2016)

• Record Type: Journal Article
• Authors: Zakharov, B. A.; Goryainov, S. V.; Boldyreva, E. V.
• Is Part Of: CrystEngComm. Volume 18:Issue 29(2016)
• Page Start: 5423
• Page End: 5428
• Publication Date: 2016-06-16
• Subjects: Crystals -- Periodicals; Crystal growth -- Periodicals; Crystallography -- Periodicals; Cristaux -- Périodiques; Cristaux -- Croissance -- Périodiques; Cristallographie -- Périodiques; 548
• DOI: 10.1039/c6ce00711b
• Languages: English
• ISSNs: 1466-8033

Abstract

Abstract : When crystals of four polymorphs – a stable α-form and three metastable ones (β-, γ-, δ-forms) – are simultaneously present in a pressure cell, immersed in a 1 : 1 pentane–isopentane mixture, the least stable β-form recrystallises exclusively into the γ-form (if no δ-form seed is present) or concomitantly into the γ- and δ-forms (if a seed of the δ-form is present). Abstract : When crystals of four polymorphs – a stable α-form and three metastable ones (β-, γ-, δ-forms) – are simultaneously present in a pressure cell, immersed in a 1 : 1 pentane–isopentane mixture, the least stable β-form recrystallises exclusively into the γ-form (if no δ-form seed is present) or concomitantly into the γ- and δ-forms (if a seed of the δ-form is present). However, the β-form never recrystallises to the stable α-form, even if the latter is also present as a potential seed.